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Search Results for " g protein-coupled receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T7428 SBI-115 GPCR19
SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
T4083 BAR501 BAR 501 GPCR19
BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).
TQ0252 BAR502 FXR , GPCR19 , Autophagy
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
T4352 SB756050 SB-756050,SB 756050 GPCR19
SB756050 is a specific TGR5 agonist.
T5077 Deoxycholic acid sodium salt Sodium deoxycholate,Sodium Desoxycholate Endogenous Metabolite , GPCR19
Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
TN2268 Tetrahydromagnolol Cannabinoid Receptor , GPR , GABA Receptor
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
T8818 TC-G 1005 GPCR19
TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
T2088 APD668 APD 668 GPR , P450 , Potassium Channel
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.
T2965 Deoxycholic acid Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic Endogenous Metabolite , GPCR19
Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio...
T16378 Ogerin Others , 5-HT Receptor , Adenosine Receptor
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak an...
T1824 TGR5 Receptor Agonist GPCR19
TGR5 is a potent TGR5(GPCR19) agonist.
T1793 MBX-2982 GPR
MBX-2982 is a selective, orally-available GPR119 agonist, used for the treatment of diabetes.
T0700 Ursodeoxycholic acid UDCA,Ursodiol Potassium Channel , Endogenous Metabolite
Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.
T2701 GSK1292263 GPR
GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.
T22996 ML-191 ERK
ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.
T2968 Hyodeoxycholic acid NSC 60672,α-Hyodeoxycholic Acid,HDCA FXR , Endogenous Metabolite , GPCR19
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
T4626 TC-O 9311 free base GPR
TC-O 9311 is a potent GPR139 agonist.
T8329 AR 231453 GPR
AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.
T2036 6-OAU GTPL5846 GPR
6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.
T8975 PSB-SB-487 Cannabinoid Receptor
PSB-SB-487 is antagonist of GPR55.
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